,Genome-wide in vivo screen identifies host molecule in promoting cancer metastasis

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Metastasis,the movement of tumor cells from a primary site to progressively colonize distant organs,is the leading cause of cancer mortality.Emerging evidences show that tumoreducated host microenvironment cooperates with tumor cells during the multiple stage of metastasis,making tumor cells evade immune attack,resistant to apoptosis,and proliferate in distant organ (Liu et al.,2016;Quail and Joyce,2013).
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