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目的:探讨新诊断2型糖尿病患者(T_2DM)并非酒精性脂肪肝(NAFLD)的相关因素。方法:比较新诊断T_2DM并NAFLD(DFL)和未合并NAFLD(NDFL)患者的各种生化指标,Logistic回归方法分析T_2DM并NAFLD的相关因素。结果:与NDFL组相比较,DFL组的体重指数(BMI)、腰围、谷丙转氨酶(ALT)、谷草转氨酶(AST)、Ln(C肽曲线下面积)[Ln(CPAUC)]、甘油三脂(TG)和尿酸明显增高(P<0.05);DFL组腰围≥85 cm,BMI≥25 kg/m~2,血脂异常、尿酸≥350μmol/L,代谢综合征和Ln(CPAUC)≥12的患者比例明显高于NDFL组(P<0.05);Logistic回归分析显示:腰围≥85 cm和Ln(CPAUC)≥12是新诊断T_2DM并NAFLD的独立危险因素(P<0.05)。结论:新诊断T_2DM患者的NAFLD与各种代谢异常密切相关,胰岛素抵抗是其主要的危险因素,反映中心性肥胖的腰围可作为其一个重要的预测因素。
Objective: To investigate the related factors of newly diagnosed type 2 diabetes (T2DM) not of alcoholic fatty liver disease (NAFLD). Methods: The biochemical indexes of patients with newly diagnosed T 2DM and NAFLD (DFL) and without NAFLD (NDFL) were compared. Logistic regression was used to analyze the related factors of T 2 DM and NAFLD. RESULTS: Compared with NDFL group, body mass index (BMI), waist circumference, alanine aminotransferase (ALT), aspartate aminotransferase (AST), Ln (TG) and uric acid (P <0.05). Patients with DFL had waist circumference ≥85 cm, BMI ≥25 kg / m ~ 2, dyslipidemia, uric acid ≥350 μmol / L, metabolic syndrome and Ln (P <0.05). Logistic regression analysis showed that waist circumference≥85 cm and Ln (CPAUC) ≥12 were independent risk factors for newly diagnosed T2DM and NAFLD (P <0.05). CONCLUSION: NAFLD in newly diagnosed T 2DM patients is closely related to various metabolic abnormalities. Insulin resistance is the major risk factor. It can be used as an important predictor of NAFLD in patients with newly diagnosed T 2DM.