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目的研究颅脑创伤患者外周血清胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)和神经元特异性烯醇化酶(neurospecific enolase,NSE)的浓度变化。方法按病情轻重(格拉斯哥评分)将40例单纯颅脑创伤病人分为轻型(11例)、中型(14例)、重型(15例)三组。用酶联免疫法测定各组不同时间点外周血GFAP和NSE蛋白水平的变化,同时进行平均动脉压、颅内压和脑灌注压的监测及预后评估并将上述结果进行方差分析。结果GFAP、NSE与病情轻重、预后、平均动脉压、颅内压和脑灌注压均具有相关性(P<0.05)。结论联合检测外周血清GFAP、NSE可以较为敏感地评估和预测外伤性脑损伤程度及预后。
Objective To study the changes of peripheral blood serum glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) in patients with traumatic brain injury. Methods According to severity of illness (Glasgow score), 40 patients with simple traumatic brain injury were divided into three groups: light (11 cases), medium (14 cases) and heavy (15 cases). The changes of GFAP and NSE protein in peripheral blood were measured by enzyme-linked immunosorbent assay. The mean arterial pressure, intracranial pressure and cerebral perfusion pressure were monitored and the prognosis was evaluated. The above results were analyzed by ANOVA. Results GFAP and NSE were correlated with severity of illness, prognosis, mean arterial pressure, intracranial pressure and cerebral perfusion pressure (P <0.05). Conclusion Combined detection of peripheral serum GFAP and NSE can evaluate and predict the extent and prognosis of traumatic brain injury more sensitively.