建立了固相萃取-超高效液相色谱三重四级杆质谱联用法同时测定水中痕量的氯霉素残留,该方法采用电喷雾电离源、多重反应监测负离子模式在5 min内完成对氯霉素的分析,方法检出限为0.2 ng/L,空白样品和实际样品的加标回收率为76.2%~104%,该方法具有操作简便,灵敏度高,重现性好的特点。 A solid-phase extraction coupled with ultra-high performance liquid chromatography triple quadrupole mass spectrometry (GC-MS / MS) was developed for the simultaneous determination of trace chloramphenicol residues in water. The electrospray ionization source and multiple reaction monitoring The detection limit of the method was 0.2 ng / L. The spiked recoveries of blank and actual samples ranged from 76.2% to 104%. This method has the advantages of simple operation, high sensitivity and good reproducibility.