论文部分内容阅读
目的 研究反复的阈下脑放电损伤认知功能的机制。方法 在大鼠前额叶皮层给予电刺激 ,建立惊厥阈下脑放电的动物模型 ,研究阈下脑放电对大鼠海马突触长时程增强 (LTP)的影响。结果 前额叶皮层电刺激可引起皮层及海马的惊厥阈下放电。持续 3min的放电可短时间抑制在海马齿状回建立的LTP ,这种抑制现象在停止刺激 5min后消失。结论 LTP抑制是阈下放电损伤短时记忆功能的机制之一。此机制可能和N -甲基天冬酸 (NMDA)受体通道异常持续开放导致细胞内钙超载有关
Objective To study the mechanism of repeated subthreshold brain discharge injury in cognitive function. Methods Electrical stimulation was given to the prefrontal cortex in rats to establish an animal model of subthreshold cerebral discharge in the convulsions and to investigate the effect of subthreshold brain discharge on the long-term potentiation (LTP) of hippocampal synapses in rats. Results Electrical stimulation of the prefrontal cortex can cause subthreshold discharge of the cortex and hippocampus in seizures. Continuous 3min discharge can inhibit the formation of LTP in the hippocampal dentate gyrus for a short time, and this inhibition disappeared after stopping the stimulus for 5min. Conclusion LTP inhibition is one of the mechanisms by which subthreshold discharge damages short-term memory. This mechanism may be associated with abnormal sustained opening of N - methyl aspartate (NMDA) receptor channels leading to intracellular calcium overload