全身性霉菌病的化学治疗进展非常缓慢,现把二性霉素B简略介绍如下。静脉注射二性霉素B:二性霉素B是唯一可以注射用的多烯族抗菌素。市售的二性霉素B是它的胆盐复合物,加水可形成胶质悬浮剂。如果溶液酸性过强或含足量电解质,则胶质凝集,溶液变混浊。此药在大多数市售的葡萄糖水溶液中十分稳定。即使不避光在室温放置(不管是否加入肝素或琥珀酸钠氢化考的松)24小时后仍不致凝集或降低生物活性。静脉注射此胶质后,大约10％生物活性存在于血浆中,与血浆蛋白牢固结合,治疗剂量时血清最 Chemotherapy for systemic mycosis progresses very slowly, now amphotericin B is briefly described below. Intravenous amphotericin B: amphotericin B is the only injectable polyethylenic antibiotic. Amphotericin B is commercially available as its bile salt complex, adding water to form a gel suspension. If the solution is too acidic or contains sufficient electrolyte, the gums aggregate and the solution becomes turbid. This medicine is very stable in most commercially available aqueous dextrose. Even after 24 hours without exposure to light at room temperature (with or without heparin or sodium succinate hydrogenated cortisone), no agglutination or reduced bioactivity was observed. After intravenous injection of this glial, about 10% of biological activity exists in the plasma, and plasma protein binding, the therapeutic dose of serum