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目的对比不同血浆靶控浓度异丙酚复合瑞芬太尼在无痛人工流产中应用效果。方法行人工流产患者400例,随机分为R0、R1、R2、P0组即异丙酚3.0、2.0、1.5、0μg/ml复合瑞芬太尼0、0.5、1.0、2.0ng/ml组。监测无创血压、心率、心电图和脉搏血氧饱和度,分别记录患者意识消失时间和恢复时间,并记录术中体动情况和术后主观感觉评分。结果R1、R2组恢复时间明显短于R0组。R0、R1组主观感觉评分明显优于R2、P0组。结论异丙酚与瑞芬太尼合用具有协同作用,但作用机制不同。以血浆靶控浓度2.0μg/ml异丙酚复合0.5ng/ml瑞芬太尼效果最佳。
Objective To compare the effect of propofol and remifentanil at different target concentrations in painless induced abortion. Methods 400 cases of induced abortion patients were randomly divided into R0, R1, R2, P0 group propofol 3.0,2.0,1.5,0 μg / ml remifentanil 0,0.5,1.0,2.0 ng / ml group. Noninvasive blood pressure, heart rate, electrocardiogram and pulse oximetry were monitored. Time of disappearance and recovery of patients’ consciousness were recorded. The intraoperative physical activity and postoperative subjective sensory score were recorded. Results The recovery time of group R1 and R2 was significantly shorter than that of group R0. The subjective sensory scores of R0 and R1 groups were significantly better than those of R2 and P0 groups. Conclusion Propofol combined with remifentanil has a synergistic effect, but the mechanism of action is different. The plasma target control concentration of 2.0μg / ml propofol 0.5ng / ml remifentanil best.