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目的：了解锌对尿毒症血透患者血细胞血清睾丸酮水平及免疫功能的影响。方法：给６０例尿毒症缺锌血透患者口服葡萄糖酸锌１００ｍｇ／ｄ，持续３～４个月，观察补锌前后嗜中性粒细胞，血红蛋白，血小板，血清睾丸酮水平及Ｔ淋巴细胞亚群百分比的含量情况。结果：补锌后尿毒症血透患者的血清锌，嗜中性粒细胞，血清睾丸酮水平，Ｔ淋巴细胞亚群百分比ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８较补锌前明显增高，差异显著（Ｐ＜００５）。补锌前后的血清锌与嗜中性粒细胞、血清睾丸酮水平、ＣＤ３呈正相关。结论：口服葡萄糖酸锌能改善尿毒症缺锌患者嗜中性粒细胞、血清睾丸酮水平及免疫功能，减轻临床症状。
Objective: To understand the effect of zinc on serum cytokines testosterone and immune function in uremic hemodialysis patients. Methods: 60 patients with uremic zinc deficiency hemodialysis patients oral zinc gluconate 100mg / d for 3 to 4 months before and after zinc supplementation, neutrophil, hemoglobin, platelets, serum testosterone levels and T lymphocyte subsets Percentage content. Results: The levels of serum zinc, neutrophil, serum testosterone and the percentages of T lymphocyte subsets CD3, CD4 and CD4 / CD8 in patients with zinc-induced hemodialysis were significantly higher than those before zinc supplementation (P <0 05). Serum zinc before and after zinc supplementation was positively correlated with neutrophil, serum testosterone and CD3. Conclusion: Oral zinc gluconate can improve neutrophil, serum testosterone and immune function in patients with zinc deficiency and reduce clinical symptoms.