论文部分内容阅读
目的:探讨基质细胞衍生因子-1α(stromal cell derived factor-1α,SDF-1α)在人脑胶质瘤中的表达及其与胶质瘤血管生成的相关性。方法:以58例人脑胶质瘤及18例正常脑组织为研究对象,应用免疫组织化学方法检测SDF-1α及CD105的表达情况,并计数CD105标记的微血管密度(microvessel density,MVD)。结果:正常脑组织中未见SDF-1α表达。SDF-1α标记指数及CD105-MVD与胶质瘤病理分级密切相关(P<0.01),SDF-1α标记指数与CD105-MVD均呈正相关(r=0.872,P<0.01)。SDF-1α表达和CD105-MVD与患者的年龄、性别及瘤体大小无明显相关性(P>0.05)。结论:SDF-1α和CD105-MVD可作为反映胶质瘤恶性程度的指标;SDF-1α在胶质瘤中表达增加可能引起胶质瘤的发生、发展;SDF-1α可能通过促进血管内皮细胞向肿瘤迁移,从而刺激肿瘤血管的生成。
Objective: To investigate the expression of stromal cell derived factor-1α (SDF-1α) in human glioma and its correlation with glioma angiogenesis. Methods: The expressions of SDF-1α and CD105 were detected by immunohistochemistry in 58 cases of human gliomas and 18 cases of normal brain tissues. The CD105-labeled microvessel density (MVD) was counted. Results: No normal SDF-1α expression in brain tissue. The index of SDF-1α and CD105-MVD were closely related to the pathological grade of glioma (P <0.01). There was a positive correlation between SDF-1α labeling index and CD105-MVD (r = 0.872, P <0.01). The expression of SDF-1α and CD105-MVD had no significant correlation with age, sex and tumor size (P> 0.05). Conclusion SDF-1α and CD105-MVD can be used as an indicator of the malignant degree of glioma. The increased expression of SDF-1α in glioma may lead to the occurrence and development of glioma. SDF-1α may promote the progression of vascular endothelial cells Tumor migration, thus stimulating the formation of tumor blood vessels.