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目的 探讨大豆异黄酮(SI)对实验性小鼠急性肝损伤的保护作用.方法 将小鼠随机分为空白组、模型对照组、SI干预组;采用四氯化碳(CCl4)制备小鼠急性肝损伤模型,SI干预组给予SI进行干预,12d后取各组血清及肝脏标本进行生化分析并进行肝组织病理学分析.结果 SI干预组与模型对照组比较,能明显降低小鼠血清的丙氨酸氨基转移酶、天门冬酸氨基转移酶含量(P＜0.05),降低肝脏指数(P＜0.05),降低大鼠血清和肝组织匀浆中的丙二醛(P＜0.05),显微镜下观察到肝细胞变性、坏死及炎症反应明显减轻,可缓解肝组织病理改变.结论 大豆异黄酮对实验性小鼠急性肝损伤具有一定的保护作用.“,”Objective To investigate the protective effect of soy isnflavone(SI) on acute liver injury in mice.Methods The mice were randomly divided into blank group,model control group and SI intervention group.Acute liver injury model was induced by carbon tetrachloride(CCl4),and SI group was given SI intervention.After 12 days,liver specimens for biochemical analysis and liver histopathology.Results Compared with the model control group,the SI intervention group could significantly reduce the serum AST and ALT levels(P ＜0.05),reduce the liver index(P ＜0.05),and reduce the serum levels of MDA(P ＜0.05).Hepatic cell degeneration,necrosis and inflammatory response were observed under the microscope,which could alleviate the pathological changes of liver tissue.Conclusion Soy isoflavones have some protective effects on acute liver injury in mice.