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目的研究一株毛壳属内生真菌Chaetomium sp.的次生代谢产物。方法采用硅胶、凝胶和半制备等多种色谱方法进行分离纯化,根据波谱学数据鉴定化合物结构。结果从发酵提取物中共分离得到10个化合物,分别鉴定为chetoseminudin B(1)、gonytolide C(2)、chaetone D(3)、1H-indole-3-carbaldehyde(4)、1H-吲哚-3-羧酸(5)、indole-3-methylethanoate(6)、3R*,4R*-二羟基-3-甲基戊烷-2-酮(7)、大黄素(8)、3β,5α,9α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one(9)、(3β,5α,6β,22E)-6-methoxyergosta-7,22-diene-3,5-diol(10)。结论化合物1~10均为首次从该菌种中分离得到。
Objective To study the secondary metabolites of Chaetomium sp. Methods The compounds were isolated and purified by silica gel, gel and semi-preparative methods. The structures of the compounds were identified by spectroscopic data. Results Ten compounds were isolated from fermented extracts and identified as chetoseminudin B (1), gonytolide C (2), chaetone D (3), 1H-indole-3-carbaldehyde (6), 3R *, 4R * -dihydroxy-3-methylpentan-2-one (7), emodin (8), 3β, 5α, 9α -trihydroxy- (22E, 24R) -ergosta-7,22-dien-6-one (3β, 5α, 6β, 22E) -6-methoxyergosta-7,22-diene-3,5-diol 10). Conclusion Compounds 1 ~ 10 were isolated from this strain for the first time.