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衰老是一种既复杂而又难以区别的生理过程,通常表现为人体的形态结构和生理功能都发生衰退和老化。这将使得老年人对药物的处置方式及反应性与青年人明显不同,常出现药物效应增强,作用时间延长及毒付反应增加等现象。有研究表明年龄为20—29岁时,毒付反应发生率为3％,年龄为70—79岁时为21％,增加了7倍。另一方面,由于老年人大多患有多种疾病,需同时应用多种药物,以致药物相互作用增加,而且大多数药理学、治疗学及药代动力学研究都在55岁以下的人群中进行,缺乏老年人的有关参
Aging is a complex and difficult to distinguish between physiological processes, usually manifested as the body’s morphological structure and physiological function of both decline and aging. This will make the old people’s way of handling drugs and reactivity distinctly different from those of young people, and often result in the phenomenon of drug effect enhancement, prolonged effect and increased response to poison. Studies have shown that the age of 20-29 years old, the poisoning reaction rate was 3%, aged 70-79 years old was 21%, an increase of 7 times. On the other hand, since most elderly people suffer from multiple diseases, multiple drugs need to be applied simultaneously, resulting in an increase in drug interactions, and most pharmacological, therapeutic and pharmacokinetic studies are conducted in people under 55 years of age , The lack of relevant information of the elderly