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研究了311例临床稳定型的慢性阻塞性肺疾病(COPD)患者的PaCO_2水平和正常的吸气肌潮气力(Tidal force)之间的关系。受试者为FEV_1/FVC<70％的50～70岁的男COPD患者。测定均在坐位进行。用氦稀释法测定肺容积后,再用肺量计测定。收集混合呼出气并取动脉化毛细血管血进行O_2和CO_2分析,计算生理无效腔和P_AO_2。将顶端有球囊的导管送入食道中段处测定跨肺压,用流速仪测定口腔流速,用Frank和Mead等容积法测定肺总阻力(R_L)和动态肺弹性(Eldyn)。并以气道阻断法测定最大吸气压(PImax)。结果①102例(32.8％)COPD患者有高碳酸血症(PaCO2>5.60kPa)伴低氧血症。无效通气量、肺阻力、Eldyn和内源性呼气末正压(PEEPi)随PaCO_2的增加而升高。②伴有
The relationship between PaCO 2 levels and normal inspiratory muscle tidal force in 311 clinically stable patients with chronic obstructive pulmonary disease (COPD) was studied. Subjects were 50-70-year-old male COPD patients with an FEV 1 / FVC <70%. Determination of sitting in place. The volume of lungs was determined by helium dilution and then spirometry. Mixed exhaled breaths were collected and arterialized capillary blood was taken for O 2 and CO 2 analyzes to calculate the physiologic void and P_AO_2. The transapical pressure was measured by inserting the balloon catheter into the middle part of the esophagus. The velocity of oral cavity was measured by flowmeter. The total lung resistance (R_L) and dynamic lung elasticity (Eldyn) were measured by Frank and Mead volumetric methods. The maximum airway pressure (PImax) was measured by airway blockade. Results ①102 cases (32.8%) of COPD patients had hypercapnia (PaCO2> 5.60kPa) with hypoxemia. Invalid ventilation, pulmonary resistance, Eldyn, and endogenous positive end expiratory pressure (PEEPi) increased with increasing PaCO 2. ② accompanied