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作者以巯甲丙脯酸单用(50毫克,一日三次),或与氢氯噻嗪合用(每日25或50毫克),测定其对20名轻、中度原发性高血压病人肾血流量、肾小球滤过率及肾素——血管紧张素系统的影响。结果,其中12名单用巯甲丙脯酸治疗4或6周的病人(第一组)血压恢复至正常水平(仰卧位舒张压<90mmHg)。肾血流量或肾小球滤过率无明显变化。血浆肾素活性比基础水平增加2—3倍。而血清和尿液的醛固酮水平则分别降低23%和35%.另外8名病人(第二组)单用巯甲丙脯酸后血压仍高,加用氢氯噻嗪,血压降至正常范围;此组病人单用或合用对肾血流动力学均无明显影响,单用巯甲丙脯酸治疗后血
The authors used captopril alone (50 mg three times a day), or combined with hydrochlorothiazide (25 or 50 mg daily), measured in 20 patients with mild to moderate essential hypertension renal blood flow, Glomerular filtration rate and renin-angiotensin system. As a result, blood pressure was restored to normal (supine diastolic pressure <90 mmHg) in 12 of the 12 patients treated with captopril for 4 or 6 weeks (group 1). No significant changes in renal blood flow or glomerular filtration rate. Plasma renin activity 2-3 times higher than the basal level. While aldosterone levels in serum and urine were reduced by 23% and 35%, respectively.Other 8 patients (group 2) had high blood pressure after addition of captopril and blood pressure dropped to the normal range with addition of hydrochlorothiazide; this group Patients alone or in combination have no significant effect on renal hemodynamics, with captopril alone after treatment of blood