原发性肝癌的病因学至今尚未研究清楚,据报告可能与黄曲霉毒素、亚硝胺化合物、农药、肝内寄生虫病、机体免疫状态、内分泌因素、营养情况、地理环境,家族等因素有关。近年来认为与乙型肝炎病毒(HBV)的感染,可能有更密切的关系。自从Blumberg发现澳大利亚抗原现称乙型肝炎表面抗原(HBsAg)以来,不仅大大推进了病毒性肝炎的研究,而且也为肝硬化、肝癌的病因学研究提供了宝贵的线索。1970年首先由Sherlock描述了原发 The etiology of primary liver cancer has not been studied so far, and it has been reported that it may be related to such factors as aflatoxins, nitrosamines, pesticides, hepatic parasitic diseases, immune status, endocrine factors, nutrition status, geographical environment and family status . In recent years, it is considered that there is a closer relationship with hepatitis B virus (HBV) infection. Since Blumberg discovered that Australian antigens are now known as hepatitis B surface antigen (HBsAg), it not only greatly advances the research on viral hepatitis, but also provides valuable clues for the etiology of liver cirrhosis and liver cancer. In 1970, Sherlock first described the origin