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本文目的是检查可移植性子宫颈癌(U27),经二十多年传代后形态的改变特征及其侵袭能力。组织学和透射电镜检查证明本瘤株已变为低分化的上皮癌;电镜检查胞浆内仅查见少数张力原纤维,细胞连接仅见半桥粒及类桥样结构,未见典型鳞状上皮癌的特征。扫描电镜检查可见癌细胞表面有两种主要表现类型:一种带有大量微绒毛;另一种表面比较光滑仅有少量泡状突起。肌肉内小块移植后3天,即见大量癌细胞脱离癌实体,向肌肉纤维之间活跃侵袭,侵袭方式主要沿肌细胞之间的自然间隙连续侵入,也见沿肌细胞表面呈阿米巴样运动,有的癌细胞表面伸出不同突起与靶细胞直接连接,有的癌细胞伸出丝状伪足,用其分叉的末端紧紧抓住靶细胞表面。在癌组织侵袭之处可见肌细胞变性、进而萎缩,最终可完全被癌细胞所代替。
The purpose of this paper is to examine the morphological changes and invasiveness of transplantable cervical cancer (U27) after more than 20 years of passage. Histology and transmission electron microscopy showed that the tumor had become poorly differentiated epithelial carcinoma. Only a few of the fibrils were seen in the cytoplasm by electron microscopy. Only the half-desmosomes and the bridge-like structures were seen in the cytoplasm. No typical squamous epithelium Cancer characteristics. Scanning electron microscopy revealed two main types of cancer cell surface manifestations: one with large amounts of microvilli and the other with a smooth surface with only a few vesicles. 3 days after intramuscular small block transplantation, that is, a large number of cancer cells from the cancer entities, the active invasion between the muscle fibers, invasion mainly along the natural gap between muscle cells continuously invaded, but also along the muscle cell surface was amoeba Some sports, and some protruding surface of the cancer cells directly connected with the target cells, and some cancer cells extending filopodia, with its bifurcated ends firmly grasp the surface of target cells. Invasion of cancer in the visible muscle cell degeneration, and then shrink, and ultimately can be completely replaced by cancer cells.