论文部分内容阅读
针对羧甲基-β-环糊精(CM-β-CD)作为手性选择剂在毛细管电泳分离手性药物中存在着分离度不大、峰形不对称、毛细管壁的吸附、基线不稳等问题,通过CM-β-CD与1-丁基-3-甲基咪唑氯离子液体([Bmim]Cl)进行阳离子交换反应,得到一种类似于离子液体的β-CD衍生物([Bmim](β-CD-OCH2COO)),并将其在毛细管电泳中作为缓冲液的手性添加剂分离盐酸布比卡因、扑尔敏,与CM-β-CD作为手性添加剂相比,分离度提高,峰型得到了改善,基线基本稳定,获得了较为理想的分离效果。
For the separation of chiral drugs by capillary electrophoresis, carboxymethyl-β-cyclodextrin (CM-β-CD) is used as a chiral selector. There is little separation, peak shape asymmetry, capillary wall adsorption, , A cation exchange reaction of CM-β-CD with 1-butyl-3-methylimidazolium chloride ionic liquid ([Bmim] Cl) gave a β-CD derivative similar to ionic liquid [ ] (β-CD-OCH2COO)), and its separation by capillary electrophoresis as a chiral additive in buffered hydrochloric acid bupivacaine, chlorpheniramine, compared with CM-β-CD as a chiral additive, Improve, the peak type has been improved, the baseline was basically stable, obtained the ideal separation effect.