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内皮素1(ET-1)是一种强血管收缩肽。Pekonen等的资料支持ET-1可能涉及肿瘤的发生和生长。ET-1为内皮素三种异构肽(ET-1,ET-2,ET-3)之一,从蛇毒中分离出来的Sarafo毒素与三种内皮素是同源物质。内皮素受体有ET_A(对ET-1有特异性作用)和ET_B(对三种ET和Sarafo毒素均敏感,无选择性)两种,人子宫肌层有ET_A和ET_R受体,但是,Pekonen未证实ET受体在平滑肌瘤上出现。为测定人子宫肌瘤上是否有ET受体,采用选择性的~(125)I·ET-1结合体和选择性ET_B的~(125)I
Endothelin 1 (ET-1) is a potent vasoconstrictor peptide. Pekonen et al.’s data support that ET-1 may be involved in tumorigenesis and growth. ET-1 is one of three isoforms of endothelin (ET-1, ET-2 and ET-3). Sara toxin isolated from snake venom is homologous to the three endothelin. Endothelin receptors have both ET_A (specific for ET-1) and ET_B (both sensitive and nonselective to all three ETs and Sarafo toxins), ET_A and ET_R receptors in the myometrium, but Pekonen ET receptor has not been confirmed in leiomyoma. To determine if there is an ET receptor on human uterine fibroids, a selective 125I I-ET-1 conjugate and a selective ET_B 125 I