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目的：观察虎金丸对肝纤维化大鼠血清Ⅲ型前胶原（procollagenⅢ，PCⅢ）、透明质酸（hyaluronicacid，HA）及层粘蛋白（laminin，LN）的动态影响。方法：采用CCl4所致肝纤维化动物模型，用放免法检测血清PCⅢ、HA、LN。结果：虎金丸能显著降低各期模型大鼠血清中HA、LN的含量，与对照组比较有显著性差异（P＜0．05，P＜0．01）。长期疗效优于秋水仙碱组。能维持血清中PCⅢ的血清含量在肝纤维化期（9、12周）基本正常，与正常对照组比较无显著性差异（P＞0．05）。结论：虎金丸能延缓肝纤维化的形成，有较好的预防和治疗效果。
Objective: To observe the dynamic effects of Hujin Pills on serum procollagen III (PC III), hyaluronic acid (HA) and laminin (LN) in hepatic fibrosis rats. METHODS: Animal models of hepatic fibrosis induced by CCl4 were used to detect serum PCIII, HA and LN by radioimmunoassay. Results: Hujin Pill can significantly reduce the serum levels of HA and LN in each phase of the model rats, and there is a significant difference compared with the control group (P<0.05, P<0.01). The long-term efficacy is better than the colchicine group. The serum level of PCIII in serum can maintain normal in liver fibrosis (9, 12 weeks), and there is no significant difference compared with the normal control group (P> 0.05). Conclusion: Hujin Pill can delay the formation of hepatic fibrosis and has better preventive and therapeutic effects.