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目的:观察腹腔注射全氟化碳(PFC)对动脉粥样硬化(AS)大鼠血清及主动脉组织一氧化氮(NO)、内皮型一氧化氮合酶(eNOS)、内皮素-1(ET-1)含量的影响,初步探讨PFC对AS大鼠内皮的可能保护作用。方法:将40只Wistar雄鼠随机分为空白对照组、动脉粥样硬化模型组、PFC低剂量组、PFC高剂量组,每组10只。除对照组用普通饲料外,其余均以高脂饲料喂养,建立实验性大鼠AS模型,治疗组在造模的同时给予不同剂量药物干预。12周后,测定各组大鼠血清及主动脉组织eNOS、NO、ET-1的含量,行HE染色观察各组大鼠主动脉病理变化。结果:模型组eNOS、NO含量显著降低,ET-1含量显著升高,与对照组比较有显著差异(P<0.05);PFC高剂量组较模型组血清及主动脉eNOS、NO含量显著升高,ET-1含量显著降低(P<0.05);PFC低剂量组与模型组相比血清中各指标差异无统计学意义,主动脉组织中ET-1含量显著降低(P<0.05);PFC高剂量组与低剂量组相比eNOS、NO含量显著升高,ET-1含量显著降低(P<0.05);PFC高剂量组较PFC低剂量组减轻AS大鼠主动脉组织形态学变化更明显。结论:PFC可能通过升高AS大鼠血清及主动脉组织eNOS、NO含量,降低ET-1含量,起到内皮保护功能,发挥抗AS的作用。
Objective: To observe the effects of intraperitoneal injection of perfluorocarbon (PFC) on the levels of nitric oxide (NO), endothelial nitric oxide synthase (eNOS) and endothelin - 1 (ET - 1) in serum and aorta of atherosclerosis rats ET-1) content of PFC on the AS rat endothelial possible protective effect. Methods: Forty Wistar male rats were randomly divided into blank control group, model group of atherosclerosis, low-dose PFC group and high-dose PFC group, with 10 rats in each group. In addition to the control group with normal feed, the rest were fed with high-fat diet, the establishment of experimental rat AS model, the treatment group at the same time giving different doses of drug intervention. After 12 weeks, the contents of eNOS, NO and ET-1 in the serum and aorta of rats in each group were determined. The pathological changes of the aorta were observed by HE staining. Results: Compared with the control group, the content of eNOS and NO in the model group decreased significantly and the content of ET-1 significantly increased (P <0.05). Compared with the model group, the content of eNOS and NO in serum and aorta of PFC high- (P <0.05). Compared with the model group, there was no significant difference in the serum ET-1 level between the PFC low dose group and the aortic root tissue (P <0.05) Compared with the low dose group, the eNOS and NO levels were significantly increased and ET-1 content was significantly decreased (P <0.05). Compared with the low dose PFC group, the PFC high dose group alleviated the morphological changes of aorta in AS rats. CONCLUSION: PFC may play an anti-AS role by increasing the content of eNOS and NO in serum and aorta and decreasing the content of ET-1 in AS rats.