为探讨旋毛虫肌肉期幼虫分泌排泄物（ＴｓＬ１ＥＳ）中４６５８ｋＤ抗原的保护性免疫作用，本文用该纯化抗原组分加福氏完全佐剂（ＦＣＡ）腹腔注射免疫昆明小鼠３次，继以旋毛虫感染性幼虫３００条攻击感染，感染后第７天计数小鼠肠道成虫数、第３０天肌肉幼虫数和血清抗体ＩｇＧ滴度。结果：４６５８ｋＤ抗原免疫鼠的肠道成虫减虫率、肌肉幼虫减虫率和血清抗体ＩｇＧ的几何平均倒数滴度分别为４１８％、４６１％和２８４１２；与ＴｓＬ１ＥＳ诱导的保护性免疫力（４８３％、５０２％和３４５８６）水平接近；显著高于佐剂对照组（４８％、８３％和７４８６）。表明：ＴｓＬ１ＥＳ中４６５８ｋＤ抗原组分可产生明显的保护性免疫作用 In order to explore the protective immunity of the 4658kD antigen in the secretion of Trichinella spiralis larvae (TsL1ES), Kunming mice were immunized three times by intraperitoneal injection of the purified antigenic component plus Freund’s complete adjuvant (FCA) Following infection with 300 infectious larvae of Trichinella, the number of intestinal tract adults, the number of muscle larvae on day 30, and the serum IgG titer were counted on the 7th day after infection. Results: The geometric mean reciprocal titers of 41.3%, 46.1%, and 28412, respectively, of intestinal adult worm reduction, muscle worm larval reduction and serum IgG were 4658kD antigen immunized mice, The level of protective immunity induced by ES (483%, 502% and 34586) was similar to that of adjuvant control group (4. 8%, 8.3% and 7486). Show: TsL1 ES in 46  58kD antigen components can produce significant protective immunity