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近年来，含凝血酶敏感素基序的去整合素金属蛋白酶（ ADAMTS）基因的异常表达与肿瘤的血管新生、发生发展以及淋巴结转移之间的关系成为很多学者的研究热点。诸多研究结果为寻找新型肿瘤标志物指明了方向，也为肿瘤分子靶向治疗提供了理论依据。该文就 ADAMTS 家族的结构、功能及其在肿瘤中的研究进展进行综述。“,”In recent years, the relationship between A disintegrin and metalloproteinase with throm-bospondin( ADAMTS) gene abnormal expression and the tumor angiogenesis, occurrence, development, lymph node metastasis became a research hotspot for many scholars.Many research results pointed out the direction for finding new tumor markers,and also provided theoretical basis for molecular targeting therapy for cancer.Here is to make a review of the structure and function of the ADAMTS family and its research pro-gress in tumor.