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目的 :研究运脾复方儿宝颗粒 (简称儿宝 )对小儿厌食症模型大鼠中枢和外周脑肠肽的调节作用。方法 :模拟小儿厌食症的主要病因制作幼龄大鼠厌食模型 ,并用儿宝治疗 ;应用放免检测技术测定模型大鼠下丘脑、胃窦部和外周血八肽胆囊收缩素 (CCK 8)和 β 内啡肽 ( β EP)的含量。 结果 :模型大鼠中枢和外周血CCK 8含量均增高 (P <0 0 5或P <0 0 1) ,外周血β EP含量减低 (P <0 0 5)。用儿宝治疗后CCK 8显著降低 ,β EP含量显著增加 (P <0 0 5或P <0 0 1)。结论 :儿宝能明显抑制该模型中枢和外周血CCK 8分泌 ,促进β EP分泌
Objective: To study the regulation effect of Yunpian Compound Erbao Granules on the central and peripheral brain-gut peptide of children with anorexia model. Methods: The anorexia model of young rats was simulated to simulate the anorexia of children with anorexia. The model of cholecystokinin (CCK 8) and β Endorphin (β EP) content. Results: The levels of CCK 8 in central and peripheral blood of model rats were increased (P <0.05 or P <0.01), and the content of β EP in peripheral blood was decreased (P <0.05). CCK 8 was significantly decreased and β EP content was significantly increased (P <0.05 or P <0.01) after treatment with Bao Bao. Conclusion: Treasure can significantly inhibit the central and peripheral blood CCK 8 secretion and promote β EP secretion