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目的观察酵母硒对小鼠艾氏腹水瘤(EAC)生长及机体氧化机能的影响。方法将30只小鼠分为3组(对照组、低剂量酵母组和高剂量酵母组),酵母硒组小鼠通过灌胃的方法分别灌注酵母硒溶液,剂量分别为107μg/kg.BW.d和214μg/kg.BW.d,灌胃第13 d接种EAC,第23 d后测定小鼠肿瘤重和血清中丙二醛(M DA)含量、谷胱甘肽过氧化酶(G SH-Px)和超氧化物歧化酶(SOD)活力。结果酵母硒可抑制小鼠EAC的生长,同时显著提高血清G SH-Px活性(P<0.05),极显著提高血清SOD活力(P<0.01),高剂量酵母硒降低血清M DA水平(P<0.05)。结论酵母硒可抑制小鼠移植肿瘤的生长,显著提高机体抗氧化能力。
Objective To observe the effect of yeast selenium on the growth of Ehrlich ascites tumor (EAC) and its oxidative function in mice. Methods Thirty mice were divided into three groups (control group, low-dose yeast group and high-dose yeast group). Yeast selenium group mice were respectively perfused with selenium solution by gavage at dose of 107μg / kg.BW. d and 214μg / kg.BW.d, and the mice were inoculated with EAC on the 13th day after gavage. Tumor weight and MDA content in the mice were measured on the 23rd day, and glutathione peroxidase (G SH- Px) and superoxide dismutase (SOD) activity. Results Yeast selenium could inhibit the growth of EAC in mice and significantly increase the activity of G-SH-Px in serum (P <0.05), significantly increase the activity of serum SOD (P <0.01), and selenium in high dose selenium decreased the level of serum M DA (P < 0.05). Conclusion Yeast selenium can inhibit the growth of mice transplanted tumors, significantly improve the body’s antioxidant capacity.