To the Editor: In clinics,.antidepressants are widely used. Due to the elevated intraocular pressure (IOP), there is less use of tricyclic antidepressant at present. However, a new type of antidepressants is also possible in the presence of acute glaucoma. Here, we report a case of bilateral acute angle-closure glaucoma associated with venlafaxine.rnA 70-year-old woman, who had a history of slow reaction for more than 2 years, was admitted to our hospital. The initial diagnosis was lacunar infarction. Although she was suffering from insomnia, her physical examination was normal. Similarly, her previous ophthalmological history was normal, and her eyesight had declined slightly in recent years. In consideration of her score of Hamilton Anxiety Scale (15 points) and Depression Scale (20 points), venlafaxine (37.5 mg, po, qd) was used in the treatment. After three days of taking venlafaxine, the patient complained of dizziness, palpitation, and poor appetite. Then,the drug was discontinued. However, five hours later, the patient complained of eye tearing with blurred vision and did not daring to open eyes. Conjunctival congestion and haze of the cea were appeared in her eyes. IOP of both eyes was more than 80 mmHg (1 mmHg=0.133 kPa). A diagnosis of acute angle-closure glaucoma was made by an ophthalmologist. Immediate therapy was commenced with a standard acute angle-closure glaucoma treatment regimen. The IOP was reduced to normal (13 mmHg in the right eye and 17 mmHg in the left eye) after giving mannitol, pilocarpine,and timolol maleate. There was no abnormality IOP after 3 days of continued treatment. After that, the patient was transferred to another hospital for eye surgery. We have been informed that she recovered during follow-up.