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81例经胃镜证实的HP阳性十二指肠溃疡患者,随机分成二组分别接受兰索拉唑三联或二联疗法根除HP治疗。服法:三联组兰索拉唑30mg,每日2次,阿莫西林0.5g及甲硝唑0.4g,每日3次;二联组兰索拉唑服法同上,阿莫西林0.5g,每日4次。疗程均为10d.结果:三联组根除率为95%(38/40),高于二联组80.5%(33/41)(P<0.05);溃疡愈合率分别为87.5%及87.8%;副反应发生率分别为15%(6/40)及4.9%(2/41),P>0.05。结果表明:兰索拉唑三联疗法具有症状缓解迅速、HP根除率高、副反应轻、依从性好等优点,是一种较理想的根除HP治疗方案。
Eighty-one patients with HP-positive duodenal ulcer confirmed by gastroscope were randomly divided into two groups to receive Lansoprazole triple or dual therapy respectively to eradicate HP. Service method: triple group of Lansoprazole 30mg, 2 times a day, amoxicillin 0.5g and metronidazole 0.4g, 3 times a day; the second group of lansoprazole treatment method Ibid, amoxicillin 0 .5g, 4 times a day. The results showed that the cure rate was 95% (38/40) in the triple group, 80.5% (33/41) in the combined group (P <0.05), and the healing rates of the ulcer were 87.5% and 87.8%; the incidence of side effects were 15% (6/40) and 4.9% (2/41) respectively, P> 0.05. The results showed that: Lansoprazole triple therapy with rapid relief of symptoms, HP eradication rate, mild side effects, and good compliance, is an ideal eradication of HP treatment options.