儿童癫癇是儿科常见的临床综合征之一，其治疗往往需要相当长的时间，加之癫癇患儿自身存在免疫缺陷问题，因此在抗癫癇治疗的同时常合用一些抗生素和化学合成抗菌药，这就可能引起一系列的药一药相互作用。本文综述了儿科常用抗癫癇药与常用抗菌药之间可能发生的相互作用。 Children with epilepsy is one of the common clinical syndrome in pediatrics, and its treatment often takes a long time, combined with the existence of immunodeficiency problems in children with epilepsy, so often in the treatment of epilepsy with some antibiotics and chemical synthesis of antibiotics, which may Cause a series of drug-drug interactions. This article summarizes the possible interactions between pediatric commonly used antiepileptic drugs and commonly used antibacterials.