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AIM:To study the plasma des-γ-carboxy protein C activity,antigen and prothrombin levels in patients with liver diseasesand their clinical significance.METHODS:Plasma protein C activity(PC:C)was detectedby chromogenic assay and antigen(PC:Ag)and des-γ-carboxyprotein C(DCPC)were detected by ELISA.Total prothrombinand unabsorbed prothrombin in plasma were detected byecarin chromogenic assay.RESULTS:Compared with the control,the levels of PC:Cand PC:Ag in patients with hepatocellular carcinoma(HCC)and liver cirrhosis(LC)were lower(PC:C:104.65±23.0%,62.50±24.89%,56.75±20.14%,PC:Ag:5.31±1.63 μg/mL,2.28±1.15 μg/mL,2.43±0.79 μg/mL,P<0.05).The levelsof PC:Ag in patients with acute viral hepatitis(AVH)alsowas lower(2.98±0.91 μg/mL,P<0.01),but PC:C was closeto the control(93.76±30.49%,P>0.05).The levels of DCPC inpatients with HCC were remarkably higher(0.69±0.29 μg/mL,1.18±0.63 μg/mL,0.45±0.21 μg/mL,P<0.05)and its averagewas up to 50% of total PC:Ag.But those of DCPC in patientswith AVH were not significantly different from the control.The levels of total prothrombin were lower in patients withLC,but higher in patients with HCC.The levels of unabsorbedprothrombin were predominantly higher than those of othergroups.CONCLUSION:PC:C and PC:Ag in patients with liverdiseases(except PC:C in AVH)were lower.The totalprothrombin was lower in patients with LC.The higherlevel of unabsorbed prothrombin may be used as a scanningmarker for HCC.DCPC may be used as a complementarymarker in the diagnosis of HCC.
AIM: To study the plasma des-γ-carboxy protein C activity, antigen and prothrombin levels in patients with liver diseases and their clinical significance. METHODS: Plasma protein C activity (PC: C) was detected by chromogenic assay and antigen (PC: Ag) and des-gamma-carboxyprotein C (DCPC) were detected by ELISA. Total prothrombin and unabsorbed prothrombin in plasma were detected byecarin chromogenic assay .RESULTS: Compared with the control, the levels of PC: Cand PC: Ag in patients with hepatocellular carcinoma (PC: C: 104.65 ± 23.0%, 62.50 ± 24.89%, 56.75 ± 20.14%, PC: Ag: 5.31 ± 1.63 μg / mL, 2.28 ± 1.15 μg / mL, 2.43 ± 0.79 μg / mL, P <0.05). The levels of PC: Ag in patients with acute viral hepatitis (AVH) alsowas lower (2.98 ± 0.91 μg / mL, P <0.01), but PC: C was closeto the control (93.76 ± 30.49 %, P> 0.05). The levels of DCPC inpatients with HCC were remarkably higher (0.69 ± 0.29 μg / mL, 1.18 ± 0.63 μg / mL, 0.45 ± 0.21 μg / mL, of total PC: Ag.But those of DCPC in patie ntswith AVH were not significantly different from the control. The levels of total prothrombin were lower in patients with LC, but higher in patients with HCC.The levels of unabsorbedprothrombin were predominantly higher than those of othergroups.CONCLUSION: PC: C and PC: Ag in patients with liverdiseases (except PC: C in AVH) were lower. The totalprothrombin was lower in patients with LC. The higherlevel of unabsorbed prothrombin may be used as a scanningmarker for HCC .DCPC may be used as a complementary marker in the diagnosis of HCC.