论文部分内容阅读
背景:作者既往研究发现海藻酸多糖衍生物有促进骨细胞生长的作用。目的:探索海藻酸多糖衍生物治疗骨质疏松的效果。方法:60只Wistar雌性大鼠随机分成对照组,治疗组和模型组,每组20只。治疗组和模型组大鼠用维甲酸诱导产生骨质疏松模型。治疗组大鼠每只每公斤每天10mg多糖衍生物灌胃,模型组每只每公斤每天10mg葡萄糖灌胃,持续2周。观察大鼠股骨病理形态学和骨组织形态计量学变化。结果与结论:与对照组相比,模型组大鼠股骨骨小梁面积、平均骨小梁厚度、骨小梁密度显著降低,而髓腔质间隔宽度则明显增加;经过海藻多糖衍生物治疗后,治疗组大鼠股骨平均骨小梁密度,平均骨小梁厚度和骨小梁面积较模型组均显著上升,同时髓腔质间隔宽度明显下降;说明海藻酸性多糖能有效促进骨细胞生长,可治疗和预防骨质疏松。
Background: The authors previously found that alginic acid polysaccharide derivatives have the effect of promoting the growth of osteocytes. Objective: To explore the effect of alginic acid polysaccharide derivatives in treating osteoporosis. Methods: Sixty Wistar female rats were randomly divided into control group, treatment group and model group, with 20 rats in each group. Rats in the treatment group and model group were induced by retinoic acid to produce osteoporosis model. The rats in the treatment group were orally administered with 10 mg of polysaccharide per kilogram per day, while the model group was orally administered with 10 mg of glucose per kilogram per day for 2 weeks. The histopathology and bone histomorphometry of rats were observed. RESULTS AND CONCLUSION: Compared with the control group, the femoral trabecular area, mean trabecular thickness and trabecular density of the model group were significantly decreased, while the width of the medullary space was significantly increased. After the treatment with seaweed polysaccharide derivative , Mean femoral trabecular bone density, average trabecular thickness and trabecular area in the treatment group were significantly increased compared with the model group, meanwhile, the width of the medullary space was significantly decreased; indicating that alginate polysaccharide can effectively promote the growth of osteocytes, Treat and prevent osteoporosis.