椎间盘退变(intervertebral disc degeneration,IDD)是引起下腰痛及腰椎间盘突出症的一个主要因素[1]。然而椎间盘退变的确切病因和病理生理机制尚不清楚,构建椎间盘退变动物模型是研究椎间盘退变的基础。建立的动物模型要与人类的椎间盘退变具有相似性和比拟性,应包括以下几个 Intervertebral disc degeneration (IDD) is a major cause of low back pain and lumbar disc herniation [1]. However, the exact etiology and pathophysiology of degenerative disc disease remains unclear. The establishment of animal models of degenerative disc disease is the basis for the study of disc degeneration. The establishment of the animal model and human degenerative disc degeneration have similarities and comparisons should include the following