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目的:探讨冠心病患者经皮冠状动脉腔内成形术( PTCA)前后,冠状循环中血小板功能的变化。方法:全部病例经PTCA前后由冠状静脉窦采血,采用生物法检测血浆中血小板活化因子( PAF)含量和采用放免方法检测血浆血栓素B2 ( TXB2 )、血浆6酮-前列腺素( 6- keto- PGF1 a)浓度。结果:38例稳定性心绞痛患者和32例不稳定性心绞痛患者PTCA术后5 min血小板活化因子( PAF)及血浆血栓素B2 ( TXB2 )明显升高,术后1 0 min达到高峰,30 min降至正常。术前与术后相比差异显著,P<0 .0 1。结论:冠心病患者PTCA术后确有血小板活化。
Objective: To investigate the changes of platelet function during coronary circulation in patients with coronary heart disease before and after percutaneous transluminal coronary angioplasty (PTCA). Methods: All cases were collected blood from the coronary sinus before and after PTCA. The levels of platelet-activating factor (PAF) in plasma were measured by bioassay and the levels of plasma TXB2 and 6-keto-prostaglandin were detected by radioimmunoassay. PGF1 a) concentration. Results: In 38 patients with stable angina and 32 patients with unstable angina pectoris, platelet activating factor (PAF) and thromboxane B2 (TXB2) were significantly increased at 5 min after PTCA, reached the peak at 10 min after operation and decreased at 30 min To normal. Preoperative and postoperative differences were significant, P <0. Conclusion: Coronary heart disease patients do have platelet activation after PTCA.