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目的探讨肝细胞生长因子(HGF)及其受体 c-Met 在活动性和非活动性溃疡性结肠炎(UC)患者结肠黏膜组织的表达意义。方法采用免疫组化 SABC 法检测活动性和非活动性 UC 患者以及对照组肠镜活检组织中 HGF、c-Met 表达;SP 法检测增殖细胞核抗原(PCNA)表达。结果对照组、活动性 UC 组、非活动性 UC 组 HGF 阳性表达率分别为25%、88%、100%;c-Met 阳性表达率分别为25%、92%、100%;组间比较有显著性差异,P 均<0.05;HGF、c-Met 在 UC 结肠黏膜表达与 PCNA过表达正相关(r 分别为0.648、0.645,P 均<0.05)。结论 HGF 及其受体 c-Met 可能在 UC 结肠炎症黏膜修复中起作用。
Objective To investigate the expression of hepatocyte growth factor (HGF) and its receptor c-Met in colonic mucosa of patients with active and inactive ulcerative colitis (UC). Methods Immunohistochemical SABC method was used to detect the expression of HGF and c-Met in active and inactive UC patients and control group. The expression of proliferating cell nuclear antigen (PCNA) was detected by SP method. Results The positive expression rates of HGF in control group, active UC group and inactive UC group were 25%, 88% and 100% respectively; the positive rates of c-Met were 25%, 92% and 100% P <0.05). The expressions of HGF and c-Met in colonic mucosa of UC were positively correlated with PCNA overexpression (r = 0.648, 0.645, P <0.05). Conclusion HGF and its receptor c-Met may play a role in mucosal repair of UC colon inflammation.