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本文比较了水提醇沉法与渗漉法对板蓝根注射液含量的影响。在渗漉法较水提醇沉法好的基础上,用正交设计对渗漉法的醇浓度、氨调pH值、灭菌前pH值等因素进行考查。实验结果表明:对含量影响的主要因素为渗漉液中氯调pH值、醇浓度和灭菌前pH值次之,第二次氨调pH对含量几乎没有影响。
This paper compares the effects of water extraction, alcohol precipitation and percolation on the content of Banlangen injection. On the basis of the osmotic method is better than the water extraction and alcohol precipitation method, the factors such as the alcohol concentration of the osmotic method, the ammonia pH value, and the pH value before sterilization are examined by the orthogonal design. The experimental results show that the main factors affecting the content are the pH value of the chlorine in the percolation liquid, the alcohol concentration and the pH value before sterilization. The pH of the second ammonia adjustment has almost no effect on the content.