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目的探讨非瓣膜病性心房颤动(房颤)伴缺血性卒中患者的复发及其影响因素。方法回顾性分析1992-2002年住院非瓣膜病性房颤伴缺血性卒中患者386例,随访收集有关临床资料,进行复发分析并研究其复发的相关因素。结果非瓣膜病性房颤伴缺血性卒中患者的10年累计复发率为34%,Cox 回归单因素分析发现,高血压、糖尿病、短暂性脑缺血发作(TIA)、高脂血症、附壁血栓是非瓣膜病性房颤伴缺血性卒中患者复发的危险因素,Cox 回归多因素分析发现高血压病,TIA 发作史与附壁血栓为非瓣膜病性房颤合并缺血性卒中复发的独立危险因素;而阿司匹林与华法林治疗对非瓣膜病性房颤合并缺血性卒中复发有保护作用。结论高血压病、TIA 发作史与附壁血栓为非瓣膜病性房颤合并缺血性卒中复发的独立危险因素,阿司匹林与华法林治疗对非瓣膜病性房颤合并缺血.陛卒中复发有保护作用。
Objective To investigate the recurrence of non-valvular atrial fibrillation (AF) patients with ischemic stroke and its influencing factors. Methods A retrospective analysis of 386 inpatients with nonvalvular atrial fibrillation and ischemic stroke from 1992 to 2002 was conducted. The clinical data were collected and followed up for relapse analysis and the related factors of recurrence. Results The 10-year cumulative recurrence rate was 34% in patients with non-valvular atrial fibrillation and ischemic stroke. Univariate analysis by Cox regression showed that hypertension, diabetes mellitus, transient ischemic attack (TIA), hyperlipidemia, Mito thrombus is a non-valvular atrial fibrillation with ischemic stroke recurrence risk factors, Cox regression multivariate analysis found that hypertension, TIA seizure history and mural thrombus non-valvular atrial fibrillation with ischemic stroke recurrence Of the independent risk factors; and aspirin and warfarin treatment of non-valvular atrial fibrillation with ischemic stroke recurrence have a protective effect. Conclusions Hypertension, history of TIA and mural thrombus are independent risk factors of non-valvular atrial fibrillation with recurrent ischemic stroke. Aspirin and warfarin are effective in treating non-valvular atrial fibrillation with ischemic stroke. Have a protective effect.