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目的研究p57KIP2在完全性水泡状胎块(CHM)与部分性水泡状胎块(PHM)中的表达情况,探讨其在水泡状胎块诊断中的意义。方法采用免疫组化方法检测p57KIP2在43例CHM及32例PHM组织中的表达情况,同时选取5例正常胎盘及5例水肿性流产胎盘组织作为对照。结果①p57KIP2表达呈组织异质性。在PHM、正常胎盘及水肿性流产胎盘绒毛细胞滋养细胞、绒毛间质细胞、绒毛间中间滋养细胞及蜕膜组织中p57KIP2均(+),而绒毛合体滋养细胞p57KIP2(-);②在CHM绒毛细胞滋养细胞和绒毛间质细胞中p57KIP2(-),与PHM中相应细胞表达情况比较差异极显著(P<0.01)。结论p57KIP2可作为CHM与PHM鉴别诊断的标记物,对CHM的诊断具有很高的灵敏度和特异度。
Objective To study the expression of p57KIP2 in complete blister-like (CHM) and partial blister-like (PHM) and to explore the significance of p57KIP2 in the diagnosis of blisters. Methods Immunohistochemistry was used to detect the expression of p57KIP2 in 43 cases of CHM and 32 cases of PHM. Meanwhile, 5 cases of normal placenta and 5 cases of edematous abortion placenta were selected as controls. Results ①p57KIP2 expression was heterogeneous. In PHM, normal placenta and edematous abortion placental villi trophoblast cells, villus mesenchyme cells, intervillous trophoblasts and decidual tissue in both p57KIP2 (+), and villous syncytium trophoblast p57KIP2 (-); ② in the CHM villi The expression of p57KIP2 (-) in cytotrophoblast and villus stromal cells was significantly different from that in PHM (P <0.01). Conclusion p57KIP2 can be used as a marker for differential diagnosis between CHM and PHM, and has high sensitivity and specificity for the diagnosis of CHM.