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目的了解肿瘤标志物在胃癌中的表达情况 ,探讨其在早期诊断中的价值。方法用 SABC染色法对 30例胃癌组织标本进行了 4种肿瘤标志物 p5 3、p2 1CIP1 、CEA和 C- erb B- 2的检测。结果 30例胃癌 p5 3、p2 1CIP1 、CEA和 C- erb B- 2的阳性表达率分别为 30 %、5 3.3%、80 %和 33.3%。结论单一肿瘤标志物 ,除 CEA外其他 3种在胃癌中的阳性表达率较低 ;联合应用 4种肿瘤标志物可提高阳性检出率 ,但 4种肿瘤标志物对早期胃癌诊断阳性率低 ,且与胃癌的分化程度无关
Objective To understand the expression of tumor markers in gastric cancer and explore its value in early diagnosis. Methods The tumor markers p53, p21 CIP1, CEA and C-erb B-2 were detected by SABC staining in 30 cases of gastric cancer. Results The positive rates of p53, p21 CIP1, CEA and C-erb B-2 in 30 cases of gastric cancer were 30%, 53.3%, 80% and 33.3%, respectively. Conclusions The positive expression rate of single tumor markers, except for CEA, is lower in gastric cancer; combined detection of four tumor markers can increase the positive detection rate, but the positive rate of four tumor markers for early gastric cancer diagnosis is low. And has nothing to do with the degree of differentiation of gastric cancer