General anesthesia is an unconscious state induced by anesthetics for surgery.The molecular targets and cellular mechanisms of general anesthetics in the mammalian nervous system have been investigated during past decades.In recent years,K+ channels have been identified as important targets of both volatile and intravenous anesthetics.This review covers achievements that have been made both on the regulatory effect of general anesthetics on the activity of K+ channels and their underlying mechanisms.Advances in research on the modulation of K+ channels by general anesthetics are summarized and categorized according to four large K+ channel families based on their amino-acid sequence homology.In addition,research achievements on the roles of K+ channels in general anesthesia in vivo,especially with regard to studies using mice with K+ channel knockout,are particularly emphasized.