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目的:研究急性心肌梗死(AMI)时脂蛋白(A)〔LP(A)〕、血小板(PLT)及蛋白激酶C(PKC)的关系.方法:分别以高LP(A)血症的AMI患者(32例)及健康对照者(32 例)为对象,采用全自动血细胞分析仪检测其PLT数量,双抗夹心ELISA单克隆抗体法测定LP(A)及液闪仪测定PLT中PKC底物40 KU 蛋白磷酸化程度,对检测结果进行统计学分析.结果:AMI组PLT数目及40 KU 蛋白磷酸化程度明显高于对照组(P＜ 0.05),且磷酸化程度随着40 KU 蛋白磷酸化反应时间的延长而增强( P＜ 0.05).结论:LP(A)是AMI的独立危险因素.高LP(A)血症的AMI患者PLT数目及PLT中PKC底物40 KU 蛋白磷酸化程度均增高“,”Objective:To study the reation of lipoprotein (a) 〔LP(a)〕、 platelet (PLT) and protein kinase C 〔PKC〕 in acute myocardial infarction (AMI).Method:The objects of this research composed of 2 groups,the group of AMI patient with high LP(a) (32 cases) and the group of healthy person(32 cases). Their level of LP(a), the amount of PLT and the level of cpm of each group were examined separately. The data obtained were analysed with statistics.Result:All data in three items mentioned above were higher in AMI group than that in control group.Conclusion:LP(a) is an independente risk factor for AMI. the number of PLT, and the level of 40 ku protein phosphorylated of PKC substracte in PLT were increased.