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目的研究医院感染洋葱伯克霍尔德菌临床分布及耐药性,为临床合理用药提供依据。方法通过回顾性分析,对某医院临床送检标本中洋葱伯克霍尔德菌检测结果进行研究。结果从该医院临床送检的不同标本中共检出洋葱伯克霍尔德菌103株,主要来自重症监护室,80%以上菌株分离自痰液标本。该细菌对复方新诺明,米诺环素等抗菌药物比较敏感,对妥布霉素,亚胺培南,庆大霉素,丁胺卡那,多粘菌素B,奈替米星,氨苄西林/舒巴坦,替卡西林/棒酸等耐药率均超过90%。结论该医院洋葱伯克霍尔德菌感染患者主要分布在重症监护室,以呼吸道感染为主,其耐药现象比较严重,应加强耐药性监测。
Objective To study the clinical distribution and drug resistance of Burkholderia cepacia in hospital and provide basis for clinical rational drug use. Methods The retrospective analysis of clinical specimens from a hospital Burkholderia cepacia test results were studied. Results A total of 103 Burkholderia cepacia were detected from different clinical samples of the hospital, mainly from intensive care unit, and more than 80% of isolates were isolated from sputum samples. The bacteria on cotrimoxazole, minocycline and other antibiotics more sensitive to tobramycin, imipenem, gentamicin, amikacin, polymyxin B, netilmicin, Ampicillin / sulbactam, ticarcillin / clavulanic acid were more than 90%. Conclusions The Burkholderia cepacia infection in the hospital is mainly distributed in the intensive care unit. It is mainly respiratory tract infection, and its drug resistance is serious. Drug resistance monitoring should be strengthened.