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对12名气喘病人进行了H~3-舒喘灵(Salbutamol)临床药理学的研究,6名患者一次口服4—8毫克,1—3小时之间发现血浆最高浓度在212微毫克分子和489微毫克分子之间。此药易吸收,并65％—84％的药量由尿排泄。血浆浓度和1—2级呼吸强度(FEV)之间有联系。在吸入0.04毫克—0.10毫克H~3-舒喘灵之后,在3—5小时发现血浆最高浓度从2.55升到5.69微毫克分子;78％—97％的剂量由尿排泄。吸入后
Twelve asthmatic patients underwent H 3- salbutamol clinical pharmacology, six patients were orally administered 4-8 mg orally, and the highest plasma concentrations were found at 212 micromoles for 1-3 hours and 489 Between micrograms of molecules. This medicine is easily absorbed, and 65% -84% of the dose is excreted by the urine. There is a link between plasma concentration and Grade 1-2 respiratory intensity (FEV). The maximum plasma concentration was found to rise from 2.55 to 5.69 micromoles at 3-5 hours after inhalation of 0.04 mg to 0.10 mg of H-3-salbutamol; 78-97% of the dose was excreted by the urine. After inhalation