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有些内耳疾病如突发性耳聋、噪音性耳聋和Meniere病认为是由于内耳供血不足引起,临床常用钙拮抗剂和抗胆碱药治疗,以提高内耳血流量。作者采用~(51)Cr标记鸡红细胞为微球,用微球技术测定维拉帕米和阿托品对兔内耳血流的作用。结果:维拉帕米组平均内耳血流量为(0.40±0.27ml)/(g·min);阿托品组为(0.37±0.22ml)/(g·min);生理盐水组为(0.11±0.10ml)/(g·min).经统计学处理,维拉帕米和阿托品与生理盐水对照比较有显著差异(P<0.01),维拉帕米与阿托品之间无显著差异(P>0.05)。说明维拉帕米和阿托品能明显增进内耳血流量。
Some diseases of the inner ear, such as sudden deafness, noise-induced deafness and Meniere’s disease, are thought to be caused by insufficient blood supply to the inner ear. Calcium antagonists and anticholinergics are commonly used clinically to increase the blood flow in the inner ear. The authors used ~ (51) Cr labeled chicken erythrocytes as microspheres, and the effect of verapamil and atropine on the rabbit inner ear blood flow was measured by microsphere technique. Results: The average inner ear blood flow in verapamil group was (0.40 ± 0.27ml) / (g · min), that of atropine group (0.37 ± 0.22ml / g · min) and saline group (0.11 ± 0.10ml ) / (g · min) .Through statistical analysis, verapamil and atropine had significant differences compared with saline control group (P <0.01), there was no significant difference between verapamil and atropine (P> 0.05). Verapamil and atropine can significantly increase the inner ear blood flow.