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以小鼠脾淋巴细胞转化，白介素２（ＩＬ－２）产生，胞内游离钙浓度（［Ｃａ２＋］ｉ），钙调蛋白量为指标，观察氯化镉（ＣｄＣｌ２，１０－２００μｍｏｌＬ－１）对脾细胞增殖的影响与细胞钙稳态的关系．结果表明，在本实验条件下，ＣｄＣｌ２对小鼠脾淋巴细胞转化，ＩＬ－２的产生有明显抑制作用，且与剂量和时间呈依赖关系．ＣｄＣｌ２对脾细胞钙稳态有干扰，致细胞［Ｃａ２＋］ｉ浓度升高，钙调蛋白量下降，也与剂量和时间呈依赖关系．提示ＣｄＣｌ２对小鼠脾细胞增殖的抑制作用与细胞钙稳态失衡密切相关．
The effects of cadmium chloride (CdCl2, 10-200 μmol L-1) on the proliferation of mouse spleen lymphocytes, production of interleukin 2 (IL-2), intracellular free calcium concentration ([Ca 2+] i) Relationship between proliferation of spleen cells and calcium homeostasis. The results showed that under the experimental conditions, CdCl2 significantly inhibited the splenic lymphocyte transformation and IL-2 production in mice and was dose-dependent and time-dependent. CdCl2 interfered with the calcium homeostasis of splenocytes, resulting in an increase in the concentration of [Ca2 +] i in the cells and a decrease in calmodulin, also in a dose-dependent manner. Tip CdCl2 inhibition of mouse spleen cell proliferation and cell calcium imbalance is closely related.