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本文以二种动物三种测痛试验方法,进行镇痛试验观察。小白鼠热板法及扭体法测定有较明显的镇痛作用;大白鼠光辐射热法,不显示镇痛效应。该制剂毒性小,催瘾试验阴性。其镇痛作用特点为起效慢,持续时间长,可以认为:上述作用是临床用于慢性持续性疼痛有效治疗的药理基础。“7955”为我院肿瘤科用于恶性肿瘤治疗的一种中草药复方制剂。在治疗过程中,非但对某些肿瘤具有疗效,而且用药后发现该制剂能促进患者入睡,并有明显镇痛作用。本文报导:“7955”的镇痛作用,急性毒性及催瘾试验结果。该复方制剂已通过鉴定,我院药厂即将投产。
In this paper, analgesic tests were performed using two kinds of animals for three kinds of pain test methods. The mice had obvious analgesic effect by the hot plate method and the writhing method. The rat radiant heat method showed no analgesic effect. The formulation was less toxic and the addiction test was negative. The analgesic effect is characterized by slow onset and long duration. It can be considered that the above-mentioned effects are the pharmacological basis for effective treatment of chronic persistent pain. “7955” is a kind of Chinese herbal compound preparation for oncology treatment in our oncology department. In the course of treatment, it is not only effective for certain tumors, but also found that the preparation can promote patients to fall asleep and have obvious analgesic effect after the drug is administered. This article reports: Analgesic effect of “7955”, acute toxicity and results of test for addiction. The compound preparation has passed the appraisal and the pharmaceutical factory in our hospital will soon be put into production.