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我院自1980年开始采用以鲎试剂法为主、家兔法为辅进行输液中热原的检测,先后检测复方氯化钠、5%和10%及50%葡萄糖、葡萄糖氯化钠、生理盐水、5%碳酸氢钠、平衡盐注射液、注射用水、0.25%盐酸普鲁卡因、生理维持液等12个品种3000批次,临床应用无任何反应,保证了制剂质量。现将检测结果及体会报告如下。一、材料和方法(一)材料(1)鲎试剂冻干品(0.1ml/支)福建省药检所制品(2)内毒素参考标准品上海生物制品所制品
In our hospital since 1980, mainly by 鲎 reagent method, supplemented by rabbit method for the detection of pyrogen in the infusion, has tested compound sodium chloride, 5% and 10% and 50% glucose, glucose and sodium chloride, physiological Saline, 5% sodium bicarbonate, balanced salt injection, water for injection, 0.25% procaine hydrochloride, physiological maintenance solution and other 12 batches of 3000 batches, no clinical application of any response to ensure the quality of the preparation. Now the test results and experience report as follows. I. Materials and Methods (1) Materials (1) 鲎 Reagents Lyophilized products (0.1ml / support) Products from Fujian Provincial Institute of Health and Pharmaceuticals (2) Endotoxin Reference Standards Shanghai Biological Products