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肿瘤的发生是一个多因素、多步骤、多阶段和多基因改变的过程 ,癌基因的功能增强与抑癌基因的突变或功能失活被认为是肿瘤发生的重要事件。最近发现的抑癌基因ＰＴＥＮ ,是至今为止发现的第一个具有双重特异性磷酸酶 (ＤＳＰ)活性和酪氨酸磷酸酶 (ＰＴＰ)活性的抑癌基因。目前
Tumor occurrence is a multifactorial, multi-step, multi-stage and multi-gene change process. The function of oncogenes and mutation or dysfunction of tumor suppressor gene are considered as important events of tumorigenesis. The recently discovered tumor suppressor gene PTEN is the first somatic tumor suppressor gene with dual-specific phosphatase (DSP) activity and tyrosine phosphatase (PTP) activity to date. Currently