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1.麻醉猫靜脉注射馬氏藜芦碱(5—25微克/公斤)毛叶藜芦碱(25微克/公斤)邢氏藜芦碱(50微克/公斤)能使血压下降20—70％,历时5—80分钟,降压时伴有心率減慢,呼吸抑制或暫停。肌肉注射10倍于靜脉注射降压量,口服15倍于靜脉注射降压量有降压作用,可維持2—3小时,唯部分动物死于实驗中。无明显快速耐受現象。 2.降压作用与腎上腺素、去甲腎上腺素无关,而与迷走神經、毒蕈碱-胆碱反应系統有关。 3.降压过程中,頸动脉加压反射減弱,刺激迷走神經及坐骨神經向中端引起的血压效应被抑制。 4.舌下动脉給药,或結扎頸內、外动脉从甲状腺上动脉給药,結果馬氏藜芦碱1微克/公斤,毛叶藜芦碱2微克/公斤,邢氏藜芦碱5微克/公斤,均可引起血压下降。 5.三种国产藜芦碱于离体兔耳及猫后肢未見直接血管扩张作用。 6.三种国产藜芦碱大量时(馬氏碱75—200微克/公斤,毛叶碱200微克/公斤,邢氏碱400微克/公斤)除引起明显的哑噁心、呕吐外,未見其他特殊症状。氯丙嗪預先应用可防止此反应。
1. Intravenous injection of veterinary drugs (5-25 μg / kg) Veratridine (25 μg / kg) Xing’s veratridine (50 μg / kg) can reduce blood pressure by 20-70% for 5 -80 minutes, depressurization accompanied by slow heart rate, respiratory depression or suspension. Intramuscular injection of 10 times the amount of intravenous injection of antihypertensive, oral 15 times the amount of intravenous injection of antihypertensive effect, can be maintained for 2-3 hours, only some of the animals died in the experiment. No obvious rapid tolerance. 2. Antihypertensive and epinephrine, norepinephrine has nothing to do with the vagus nerve, muscarinic - choline reaction system. 3. During the antihypertensive process, carotid pressure reflex decreased, to stimulate the vagus nerve and sciatic nerve to the middle of the blood pressure effect is suppressed. Sublingual artery administration, or ligation of the internal and external carotid artery from the thyroid artery administration, the results of verapamil 1 microgram / kg, veratridine 2 micrograms / kg, Xing’s veratridine 5 micrograms / kg , Can cause blood pressure drop. 5. Three kinds of domestic veratridine in vitro rabbit ears and cat hind limb no direct vasodilatation. 6. Three kinds of domestic veratridine in large quantities (Markov 75-200 micrograms / kg, phytoalexin 200 micrograms / kg, Xing alkali 400 micrograms / kg) in addition to causing obvious dumb nausea, vomiting, no other Special symptoms. Pre-application of chlorpromazine prevents this reaction.