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原发性甲状腺功能减退症(甲减)的患儿可表现为青春期发育异常。为了探讨甲减患儿青春期发育异常的原因,作者系统地研究3例甲减患儿,其中男1例,女2例,年龄10.9～15.5岁。表现为青春期发育异常,骨龄延迟1.5～7.0年,血清甲状腺素(T_4)降低,甲状腺刺激激素(TSH)升高。用甲状腺素100μg/M~2/24h 替代治疗3～6个月,治疗前后分别测定血浆生长激素(GH)、促泌素(PRL)、黄体生成素(LH)、卵泡刺激素(FSH)、TSH;做垂体CT 扫描检查,女孩还做卵巢超声检查。结果①LH 和 FSH:正常青春期儿童 LH 高
Children with primary hypothyroidism (hypothyroidism) can be manifested as adolescent dysplasia. In order to explore the causes of hypothyroidism in adolescent dysplasia, the author systematically studied 3 cases of hypothyroidism in children, including 1 males and 2 females, aged 10.9 to 15.5 years. Manifested as puberty dysplasia, delayed 1.5 ~ 7.0 years of bone age, serum thyroxine (T_4) decreased, thyroid stimulating hormone (TSH) increased. The levels of plasma GH, PRL, LH, FSH were measured before and after treatment with 100 μg / M ~ 2 / 24h thyroid hormone for 3 to 6 months. TSH; do pituitary CT scan examination, the girl also ovarian ultrasound. Results ① LH and FSH: LH in normal adolescent children