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近年来国内外临床实践和临床药学试验研究证明,同一药物制成的片剂,由于生产工艺和辅料等各异,出现不同的治疗效果和毒副作用。因此,测定片剂的生物利用度以确保患者长期用药的有效和安全是很有必要的。鉴于国内各厂生产苯妥英钠片的工艺和原辅料不尽相同。因此,我们通过用实验动物家兔,对天津、南京等三个药厂生产的三个批号苯妥英钠片做了体外释放度测定,通过方差分析进行比较,并以单次口服后不同时间血药浓度的测定算出生物利用度。进行方差分析,比较不同药厂生产的苯妥英钠片生
In recent years, clinical trials at home and abroad and clinical trials prove that tablets made of the same drug, due to different production processes and excipients, there are different therapeutic effects and side effects. Therefore, it is necessary to determine the bioavailability of tablets in order to ensure the long-term efficacy and safety of patients. In view of the domestic plant production of phenytoin sodium tablets and raw materials are not the same. Therefore, we tested the in vitro drug release of three batches of phenytoin sodium tablets produced by three pharmaceutical factories in Tianjin and Nanjing using experimental animals and rabbits, and compared them by ANOVA. Blood samples were taken at different times after single oral administration Measurement of the concentration calculates the bioavailability. ANOVA was performed to compare the phenytoin sodium tablets produced by different pharmaceutical companies