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体外实验观察肺表面活性物质主要成分卵、脑磷脂对石英毒作用下肺泡巨噬细胞的影响。结果表明:卵磷脂可以保护肺泡巨噬细胞,减轻石英的毒作用,脑磷脂则无此作用,进一步分析其机理,发现卵磷脂可以抑制肺泡巨噬细胞在石英毒作用下活性氧的产生,而脑磷脂则否。
In vitro experiments were performed to observe the effects of egg and phosphatidylcholine on the alveolar macrophages under quartz toxicity. The results showed that lecithin can protect alveolar macrophages and reduce the toxic effects of quartz. Brain phospholipids have no such effect. Further analysis of the mechanism reveals that lecithin can inhibit the generation of reactive oxygen species in alveolar macrophages under the action of quartz toxicity. No brain phospholipids.