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目的总结大剂量顺铂＋阿霉素方案经导管髂内动脉灌注治疗膀胱癌的近期疗效。方法对７６例经病理证实且肾功能正常的膀胱癌患者行大剂量顺铂＋阿霉素髂内动脉灌注化疗。对比观察治疗前后肿瘤组织病理及超微结构的变化。结果７６例患者中，完全缓解（ＣＲ）１１例（１４．４７％），部分缓解（ＰＲ）４５例（５９．２１％），无效者２０例（２６．３２％），总反应率７３．６８％。有病理学资料的４２例患者中，化疗后，８例（１９．０５％）移行细胞癌肿瘤分级有所降低，６例（１４．２９％）病理学检查肿瘤细胞消失。肿瘤细胞超微结构的改变明显。结论大剂量顺铂＋阿霉素方案对于膀胱癌疗效明显，值得推广，但肾功能异常者应慎用该方案
Objective To summarize the short-term curative effect of high-dose cisplatin plus doxorubicin in the treatment of bladder cancer by catheterization of internal iliac artery. Methods 76 cases of bladder cancer confirmed by pathology and normal renal function underwent high-dose cisplatin + doxorubicin internal iliac artery infusion chemotherapy. The changes of tumor tissue pathology and ultrastructure were observed before and after treatment. Results Of the 76 patients, 11 (14.47%) had complete remission (CR), 45 (59.21%) had partial response (PR), 20 (26.32%) had ineffectiveness and the overall response rate was 73. 68%. Among the 42 patients with pathological data, the tumor grade of 8 cases (19.05%) of transitional cell carcinoma decreased after chemotherapy, and the tumor cells disappeared in 6 cases (14.29%) pathologically. The ultrastructure of tumor cells changed obviously. Conclusion High-dose cisplatin + doxorubicin has obvious curative effect on bladder cancer, which is worth to be popularized. However, it should be used with caution in patients with abnormal renal function